Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

作者：Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung‐Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songtao Shi, Songlin Wang · 发表于：PLoS ONE · 年份：2006 · DOI：10.1371/journal.pone.0000079 · 被引用次数：1363 · 研究领域：Mesenchymal stem cell research、Periodontal Regeneration and Treatments、Tissue Engineering and Regenerative Medicine

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.