Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis

作者：Fabian Wong, Mitra K. Nadim, John A. Kellum, Francesco Salerno, Rinaldo Bellomo, Alexander L. Gerbes, P. Angeli, Richard Moreau, Andrew Davenport, Rajiv Jalan, Claudio Ronco, Yuri Genyk, Vicente Arroyo · 发表于：Gut · 年份：2011 · DOI：10.1136/gut.2010.236133 · 被引用次数：415 · 研究领域：Liver Disease and Transplantation、Acute Kidney Injury Research、Chemotherapy-induced organ toxicity mitigation

OBJECTIVES: To propose an improvement on the current classification of renal dysfunction in cirrhosis. Clinicians caring for patients with cirrhosis recognize that the development of renal dysfunction is associated with significant morbidity and mortality. While most cases of renal dysfunction in cirrhosis are functional in nature, developed as a result of changes in haemodynamics, cardiac function, and renal auto-regulation, there is an increasing number of patients with cirrhosis and structural changes in their kidney as a cause of renal dysfunction. Therefore, there is a need for a newer classification to include both functional and structural renal diseases. DESIGN: A working party consisting of specialists from multiple disciplines conducted literature search and developed summary statements, incorporating the renal dysfunction classification used in nephrology. These were discussed and revised to produce this proposal. SETTING: Multi-disciplinary international meeting. PATIENTS: None. INTERVENTIONS: Literature search using keywords of cirrhosis, renal dysfunction, acute kidney injury (AKI), chronic kidney injury (CKD), and hepatorenal syndrome. RESULTS: Acute kidney injury will include all causes of acute deterioration of renal function as indicated by an increase in serum creatinine of >50% from baseline, or a rise in serum creatinine of ≥ 26.4 µmol/L (≥ 0.3 mg/dL) in < 48 hours. Chronic renal disease will be defined as an estimated glomerular filtration rate (GFR) of ...