Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

作者：Yitong Liu, Haiping Hao, Hong‐Guang Xie, Li Sze Lai, Qiong Wang, Changxiao Liu, Guangji Wang · 发表于：Drug Metabolism and Disposition · 年份：2010 · DOI：10.1124/dmd.110.033936 · 被引用次数：343 · 研究领域：Berberine and alkaloids research、Alkaloids: synthesis and pharmacology、Plant-based Medicinal Research