Identifying treatment responders and predictors of improvement after cognitive-behavioral therapy for juvenile fibromyalgia

作者：Soumitri Sil, Lesley M. Arnold, A. Lynch-Jordan, Tracy V. Ting, James Peugh, Natoshia R. Cunningham, Scott W. Powers, Daniel J. Lovell, Philip J. Hashkes, Murray H. Passo, Kenneth N. Schikler, Susmita Kashikar‐Zuck · 发表于：Pain · 年份：2014 · DOI：10.1016/j.pain.2014.03.005 · 被引用次数：72 · 研究领域：Pediatric Pain Management Techniques、Cerebral Palsy and Movement Disorders、Musculoskeletal pain and rehabilitation

The primary objective of this study was to estimate a clinically significant and quantifiable change in functional disability to identify treatment responders in a clinical trial of cognitive-behavioral therapy (CBT) for youth with juvenile fibromyalgia (JFM). The second objective was to examine whether baseline functional disability (Functional Disability Inventory), pain intensity, depressive symptoms (Children's Depression Inventory), coping self-efficacy (Pain Coping Questionnaire), and parental pain history predicted treatment response in disability at 6-month follow-up. Participants were 100 adolescents (11-18 years of age) with JFM enrolled in a recently published clinical trial comparing CBT to a fibromyalgia education (FE) intervention. Patients were identified as achieving a clinically significant change in disability (i.e., were considered treatment responders) if they achieved both a reliable magnitude of change (estimated as a > or = 7.8-point reduction on the FDI) using the Reliable Change Index, and a reduction in FDI disability grade based on established clinical reference points. Using this rigorous standard, 40% of patients who received CBT (20 of 50) were identified as treatment responders, compared to 28% who received FE (14 of 50). For CBT, patients with greater initial disability and higher coping efficacy were significantly more likely to achieve a clinically significant improvement in functioning. Pain intensity, depressive symptoms, and parent pain hi...