Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation.

作者：Catherine M Kolf, Elizabeth Cho, Rocky S. Tuan · 发表于：Arthritis Research & Therapy · 年份：2007 · DOI：10.1186/ar2116 · 被引用次数：912 · 研究领域：Mesenchymal stem cell research、Tissue Engineering and Regenerative Medicine、Muscle Physiology and Disorders

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.