Comparison of Antiplaque Agents Using an In Vitro Assay Reflecting Oral Conditions

作者：Richard T. Evans, Peter Baker, Robert A. Coburn, Robert J. Genco · 发表于：Journal of Dental Research · 年份：1977 · DOI：10.1177/00220345770560060201 · 被引用次数：36 · 研究领域：Oral microbiology and periodontitis research、Inflammatory mediators and NSAID effects、Oral and gingival health research

An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.