Molecular mechanisms of paraquat-induced acute lung injury: a current review

作者：Lingjie Xu, Jun Xu, Zhong Wang · 发表于：Drug and Chemical Toxicology · 年份：2014 · DOI：10.3109/01480545.2013.834361 · 被引用次数：59 · 研究领域：Paraquat toxicity studies and treatments、Plant responses to water stress、Heme Oxygenase-1 and Carbon Monoxide

Paraquat is an organic heterocyclic herbicide that is widely used in agriculture, especially in Asian countries. The prevalence of paraquat poisonings has increased dramatically in the past two decades in China. Nearly all paraquat poisonings resulted from intentional or accidental oral administration leading to acute lung injury and, ultimately, acute respiratory distress syndrome. The mortality rate has been reported to be greater than 90%. However, the exact toxic mechanism remains unclear. Herein, we reviewed and summarized the most recent publications related to the molecular mechanisms of paraquat-induced acute lung injury.