Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma

作者：Zuhu Yu, Qiang Zhang, Yadong Wang, Jing Chen, Zhimao Jiang, Min Shi, Xin Guo, Jie Qin, Guanghui Cui, Zhiming Cai, Yaoting Gui, Yongqing Lai · 发表于：Asian Pacific Journal of Cancer Prevention · 年份：2013 · DOI：10.7314/apjcp.2013.14.6.3729 · 被引用次数：19 · 研究领域：Inflammatory mediators and NSAID effects、Estrogen and related hormone effects、Hormonal Regulation and Hypertension

The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognostic value. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative real- time polymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and 91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1 expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 in RCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemical assays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated high expression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p = 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients with high expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. This is the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affected patients.