Sub-threshold Ca 2+ waves

作者：J. W. Shuai, Peter Jung · 发表于：New Journal of Physics · 年份：2003 · DOI：10.1088/1367-2630/5/1/132 · 被引用次数：17 · 研究领域：Ion channel regulation and function、Cardiac electrophysiology and arrhythmias、Receptor Mechanisms and Signaling

In this paper we consider a model for intracellular Ca 2+ waves where the ion channels (excitability) is distributed in spatially distinct clusters. We report that channel noise in conjunction with spatial clustering can result in the onset of spatially and temporally extremely coherent Ca 2+ signals at levels of stimulant well below the threshold of Ca 2+ oscillations for homogeneously distributed channels. The physiological significance of this phenomenon is strongly enhanced cellular Ca 2+ -signalling capability with few agonist molecules binding.