A new family of G-protein regulators — the RGS proteins

作者：Michael R. Koelle · 发表于：Current Opinion in Cell Biology · 年份：1997 · DOI：10.1016/s0955-0674(97)80055-5 · 被引用次数：207 · 研究领域：Protein Kinase Regulation and GTPase Signaling、Metabolism, Diabetes, and Cancer

Genetic experiments have recently been used to identify a family of 'regulator of G-protein signaling' (RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The first biochemical studies of RGS proteins have shown that they accelerate the GTPase activities of G-protein alpha subunits, thus driving G proteins into their inactive GDP-bound forms. The physiological significance of the large number of different RGS proteins remains to be explored.