Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms

作者：Antonia Nostro, Andrea Sudano Roccaro, Giuseppe Bisignano, Andreana Marino, Maria Angela Cannatelli, Francesco Pizzimenti, Pier Luigi Cioni, F. Procopio, Anna Rita Blanco · 发表于：Journal of Medical Microbiology · 年份：2007 · DOI：10.1099/jmm.0.46804-0 · 被引用次数：558 · 研究领域：Essential Oils and Antimicrobial Activity、Bacterial biofilms and quorum sensing、Advanced Chemical Sensor Technologies

The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus (n=6) and S. epidermidis (n=6) strains tested, the biofilm inhibitory concentration (0.125-0.500 %, v/v, for oregano, and 0.031-0.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.25-1.0 %, v/v, for oregano and 0.125-0.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.