Intra HLA–D Region Recombinant Maps HLA–DR between HLA–B and HLA–D

作者：J. A. Sachs, Dolores Jaraquemada, HILLIARD FESTENSTEIN · 发表于：Tissue Antigens · 年份：1981 · DOI：10.1111/j.1399-0039.1981.tb00665.x · 被引用次数：31 · 研究领域：Immunodeficiency and Autoimmune Disorders、T-cell and B-cell Immunology、Blood groups and transfusion

A consanguineous family has been typed for HLA-A, B, C, D, DR and GLO, Bf, C2 and C4 and other red cell markers. The results indicate that an expected Dw7 homozygous sibling is a "Dw1"/Dw7 recombinant, probably derived from a crossing over between DR and D on the paternal haplotypes. The anomalous typings by Dw1 HTCs of the recombinant haplotype are best explained by the likely presence of an additional Lad polymorphism which could be a serologically detectable second epitope on the same molecule as the HLA-D determinant or in the form of two linked chains, one encoded by HLA-D and one by another Lad gene in the HLA haplotype.