Spontaneous progression of ligature induced peri‐implantitis at implants with different surface roughness: an experimental study in dogs

作者：Tord Berglundh, Klaus Gotfredsen, Nicola U. Zitzmann, Niklaus P. Lang, Jan Lindhe · 发表于：Clinical Oral Implants Research · 年份：2007 · DOI：10.1111/j.1600-0501.2007.01397.x · 被引用次数：214 · 研究领域：Dental Implant Techniques and Outcomes、Bone Tissue Engineering Materials、Bone health and osteoporosis research

BACKGROUND: Peri-implantitis is associated with the presence of submarginal plaque, soft-tissue inflammation and advanced breakdown of the supporting bone. The progression of peri-implantitis following varying periods of continuing plaque accumulation has been studied in animal models. OBJECTIVE: The aim of the current experiment was to study the progression of peri-implantitis around implants with different surface roughness. MATERIAL AND METHODS: In five beagle dogs, three implants with either a sandblasted acid-etched surface (SLA) or a polished surface (P) were installed bilaterally in the edentulous premolar regions. After 3 months on a plaque control regimen, experimental peri-implantitis was induced by ligature placement and plaque accumulation was allowed to progress until about 40% of the height of the supporting bone had been lost. After this 4-month period, ligatures were removed and plaque accumulation was continued for an additional 5 months. Radiographs of all implant sites were obtained before and after 'active' experimental peri-implantitis as well as at the end of the experiment. Biopsies were harvested and the tissue samples were prepared for light microscopy. The sections were used for histometric and morphometric examinations. RESULTS: The radiographic examinations indicated that similar amounts of bone loss occurred at SLA and P sites during the active breakdown period, while the progression of bone loss was larger at SLA than at polished sites following ...