The Changing Clinical Patterns of Primary Hyperparathyroidism in Chinese Patients: Data from 2000 to 2010 in a Single Clinical Center

作者：Lin Zhao, Jianmin Liu, Xiaoyan He, Hongyan Zhao, Li‐hao Sun, Bei Tao, Min-jia Zhang, Xi Chen, Weiqing Wang, Guang Ning · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：2013 · DOI：10.1210/jc.2012-2914 · 被引用次数：112 · 研究领域：Parathyroid Disorders and Treatments、Thyroid and Parathyroid Surgery、Vitamin D Research Studies

CONTEXT: In Western countries, most patients with primary hyperparathyroidism (PHPT) are asymptomatic. The incidence of parathyroid cancer is as low as 1% but is trending upward. The clinical outlook for Chinese patients with PHPT is unclear. OBJECTIVE: Our objective was to describe the changing clinical patterns of benign and malignant PHPT in Chinese patients from 2000 to 2010. DESIGN AND SETTING: This was a cross-sectional study. SUBJECTS: A total of 249 patients with PHPT were studied. MAIN OUTCOME MEASURES: The clinical manifestations and biochemical abnormalities of PHPT were analyzed. RESULTS: Of our patients with PHPT, 61.4% were symptomatic, but asymptomatic PHPT has increased from <21% in 2000-2006 to 42.4% to 52.5% in 2007-2010. Of asymptomatic patients, 48.9% came to our center because of elevation of serum calcium levels, and another 46.9% came because of parathyroid nodule(s) incidentally discovered by thyroid ultrasonography, with a steady increase from 18.3% before 2007 to 35.7% in 2007-2008 and 61.5% in 2009-2010. Serum calcium and PTH concentrations greater than 2.77 mmol/L (area under the curve, 0.995; P < .001) and 316.3 pg/dL (area under the curve, 0.842; P < .001), respectively, are responsible for symptom development. The occurrence of parathyroid carcinoma was as high as 5.96%, but a trend downward from 10.53% to 4.44% was observed. CONCLUSIONS: The overall clinical and biochemical features of PHPT in Chinese patients are still classic, but the disease...