Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells

作者：Hao Zhuang, Manyin Zhao, Kaiwen Hei, Baicai Yang, Li Sun, Xue Du, Yongmei Li · 发表于：Asian Pacific Journal of Cancer Prevention · 年份：2015 · DOI：10.7314/apjcp.2015.16.8.3325 · 被引用次数：22 · 研究领域：Cancer Mechanisms and Therapy、Mechanisms of cancer metastasis、Circular RNAs in diseases

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients. Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration of SKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovarian cancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression. The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic and therapeutic target for ovarian cancer.