High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-Lactamases in Dar es Salaam, Tanzania

作者：Bjørn Blomberg, Roland Jureen, Karim Premji Manji, Bushir S. Tamim, Davis Mwakagile, Willy K Urassa, Maulidi Rashidi Fataki, Viola Msangi, Marit Gjerde Tellevik, Samwel Y Maselle, Nina Langeland · 发表于：Journal of Clinical Microbiology · 年份：2005 · DOI：10.1128/jcm.43.2.745-749.2005 · 被引用次数：232 · 研究领域：Antibiotic Resistance in Bacteria、Vibrio bacteria research studies、Bacterial Identification and Susceptibility Testing

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.