High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis

作者：Ganesh Raghu, Todd D. Freudenberger, Shuo Yang, J. Randall Curtis, C. Spada, Jennifer M. Hayes, J. K. Sillery, Charles E. Pope, Carlos A. Pellegrini · 发表于：European Respiratory Journal · 年份：2005 · DOI：10.1183/09031936.06.00037005 · 被引用次数：647 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Respiratory and Cough-Related Research、Eosinophilic Esophagitis

The aim of this prospective study was to determine the prevalence and characteristics of acid gastro-oesophageal reflux (GER) in patients with idiopathic pulmonary fibrosis (IPF). Sixty-five consecutive patients with well-defined IPF were subjected to 24-h pH monitoring and oesophageal manometry. A total of 133 consecutive patients with intractable asthma and symptoms of GER were used as comparisons. The prevalence of abnormal acid GER in IPF patients was 87%, with 76% and 63% demonstrating abnormal distal and proximal oesophageal acid exposures, respectively. Abnormal acid GER was significantly more common in IPF patients than asthma patients. Only 47% of IPF patients experienced classic GER symptoms. Despite treatment with standard doses of proton pump inhibitors (PPIs), 12 out of 19 patients receiving PPIs during the 24-h pH monitoring had abnormal oesophageal acid exposures by pH probe. There was no correlation between IPF severity and acid GER severity. In conclusion, abnormal acid gastro-oesophageal reflux is highly prevalent, but often clinically occult in patients with idiopathic pulmonary fibrosis. Standard doses of proton pump inhibitors may not suppress the acid gastro-oesophageal reflux in this population. Therefore, further studies are needed to determine if acid abnormal gastro-oesophageal reflux represents an important risk factor for idiopathic pulmonary fibrosis development or progression, and if optimal suppression of acid gastro-oesophageal reflux slows the...