Fully Resolved NMR Correlation Spectroscopy

作者：Daisy Pitoux, Bertrand Plainchont, Denis Merlet, Zhaoyu Hu, David Bonnaffé, Jonathan Farjon, Nicolas Giraud · 发表于：Chemistry - A European Journal · 年份：2015 · DOI：10.1002/chem.201501182 · 被引用次数：52 · 研究领域：Molecular spectroscopy and chirality、Spectroscopy and Quantum Chemical Studies、Advanced NMR Techniques and Applications

A new correlation experiment cited as "push-G-SERF" is reported. In the resulting phased 2D spectrum, the chemical shift information is selected along the direct dimension, whereas scalar couplings involving a selected proton nucleus are edited in the indirect domain. The robustness of this pulse sequence is demonstrated on compounds with increasing structural and spectral complexity, using state-of-the-art spectrometers. It allows for full resolution of both dimensions of the spectrum, yielding a straightforward assignment and measurement of the coupling network around a given proton in the molecule. This experiment is intended for chemists who want to address efficiently the structural analysis of molecules with an overcrowded spectrum.