A Well‐Defined Complex for Palladium‐Catalyzed Aerobic Oxidation of Alcohols: Design, Synthesis, and Mechanistic Considerations

作者：David R. Jensen, Mitchell J. Schultz, Jaime A. Mueller, Matthew S. Sigman · 发表于：Angewandte Chemie International Edition · 年份：2003 · DOI：10.1002/anie.200351997 · 被引用次数：300 · 研究领域：Oxidative Organic Chemistry Reactions、Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods

A breath of fresh air: A variety of alcohols are oxidized using 0.5–0.1 mol % of the catalyst, and in some cases the oxidation can simply be carried out open to the air (see scheme). Mechanistic insight into the mechanism is provided by a crystal structure that shows remarkable hydrogen bonds between the coordinated water and acetate ligands and an unprecedented large kinetic isotope effect.