Mechanisms of Fluid and Electrolyte Retention in Experimental Preparations in Dogs

作者：James O. Davis, David S. Howell, James L. Southworth · 发表于：Circulation Research · 年份：1953 · DOI：10.1161/01.res.1.3.260 · 被引用次数：74 · 研究领域：Veterinary Medicine and Surgery、Electrolyte and hormonal disorders、Adrenal Hormones and Disorders

The role of the adrenal cortex in the pathogenesis of ascites has been studied in adrenalectomized dogs with thoracic inferior caval constriction. Discontinuation of hormone therapy resulted in a diuresis which demonstrates that adequate adrenocortical function or replacement therapy is essential for ascites formation during normal sodium (Na) intake. Evidence is presented in support of the thesis that sodium retention results from an excess of circulating adrenocortical salt-retaining hormones.