DNA Gyrase: Structure and Function

作者：Richard J. Reece, Anthony Maxwell · 发表于：Critical Reviews in Biochemistry and Molecular Biology · 年份：1991 · DOI：10.3109/10409239109114072 · 被引用次数：736 · 研究领域：Cancer therapeutics and mechanisms、DNA and Nucleic Acid Chemistry、Bioactive Compounds and Antitumor Agents

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA. The mechanism by which gyrase is able to influence the topological state of DNA molecules is of inherent interest from an enzymological standpoint. In addition, much attention has been focused on DNA gyrase as the intracellular target of a number of antibacterial agents as a paradigm for other DNA topoisomerases. In this review we summarize the current knowledge concerning DNA gyrase by addressing a wide range of aspects of the study of this enzyme.