Serum-Based DNA Methylation Biomarkers in Colorectal Cancer: Potential for Screening and Early Detection

作者：Thomas A. Summers, Russell C. Langan, Aviram Nissan, Björn L.D.M. Brücher, Anton J. Bilchik, Mladjan Protić, Martin Däumer, Itzhak Avital, Alexander Stojadinovic · 发表于：Journal of Cancer · 年份：2013 · DOI：10.7150/jca.5839 · 被引用次数：43 · 研究领域：Colorectal Cancer Screening and Detection、Epigenetics and DNA Methylation、Genetic factors in colorectal cancer

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.