Inhibition of Sterol Biosynthesis in Candida albicans by Imidazole-containing Antifungals

作者：M. S. Marriott · 发表于：Microbiology · 年份：1980 · DOI：10.1099/00221287-117-1-253 · 被引用次数：94 · 研究领域：Antifungal resistance and susceptibility、Mycotoxins in Agriculture and Food、Coccidia and coccidiosis research

A simple procedure for studying sterol biosynthesis in cell-free homogenates of Candida albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation have been determined using this technique.