Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders

作者：Yan Zhang, Rongrong Mao, Zhifang Chen, Meng Tian, Dali Tong, Zhengrun Gao, Min Huang, Xiao Li, Xiu Xu, Wenhao Zhou, Chengyu Li, Jiang Wang, Lin Xu, Zilong Qiu · 发表于：Molecular Brain · 年份：2014 · DOI：10.1186/1756-6606-7-11 · 被引用次数：68 · 研究领域：Transcranial Magnetic Stimulation Studies、Neurogenesis and neuroplasticity mechanisms、Planarian Biology and Electrostimulation

BACKGROUND: Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. RESULTS: Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. CONCLUSIONS: Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.