Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway

作者：Ravi Iyengar · 发表于：Science · 年份：1996 · DOI：10.1126/science.271.5248.461 · 被引用次数：126 · 研究领域：Protein Kinase Regulation and GTPase Signaling、Phosphodiesterase function and regulation、Bioactive Compounds and Antitumor Agents

The intracellular signal transduction pathway that utilizes cyclic AMP as a key messenger was the first such pathway to be described and has served as a model for many other transducing systems. Now Iyengar illustrates how this classic pathway has yet another function—in a number of different biological systems, the cyclic AMP pathway appears to gate (either negatively or positively) other signal transduction pathways.