Nutrient Sensing, Autophagy, and Diabetic Nephropathy

作者：Shinji Kume, Merlin C. Thomas, Daisuke Koya · 发表于：Diabetes · 年份：2011 · DOI：10.2337/db11-0555 · 被引用次数：159 · 研究领域：Pancreatic function and diabetes、Metabolism, Diabetes, and Cancer、Diet, Metabolism, and Disease

The prevalence of diabetic nephropathy, a seriouscomplication of diabetes, has been increasingworldwide. Therefore, there is an urgent need toidentify a new therapeutic target to prevent di-abetic nephropathy. “Nutrient-sensing ” pathways are gen-erally well conserved among eukaryotes. Accumulating evidence indicates that alteration of nutrient-sensing pathways and subsequent impairment of cell function in insulin-sensitive organs of mammals are involved in the pathogenesis of type 2 diabetes. According to recent reports, nutrient-sensing in the kidney also seems to be altered under diabetic conditions. In this review, we dis-cuss the possibility that nutrient-sensing pathways can be a therapeutic target for diabetic nephropathy and suggest future directions for research.