Conformational Dynamics of the Chromatin Fiber in Solution: Determinants, Mechanisms, and Functions

作者：Jeffrey C. Hansen · 发表于：Annual Review of Biophysics and Biomolecular Structure · 年份：2002 · DOI：10.1146/annurev.biophys.31.101101.140858 · 被引用次数：558 · 研究领域：Genomics and Chromatin Dynamics、Ubiquitin and proteasome pathways、Protein Degradation and Inhibitors

Chromatin fibers are dynamic macromolecular assemblages that are intimately involved in nuclear function. This review focuses on recent advances centered on the molecular mechanisms and determinants of chromatin fiber dynamics in solution. Major points of emphasis are the functions of the core histone tail domains, linker histones, and a new class of proteins that assemble supramolecular chromatin structures. The discussion of important structural issues is set against a background of possible functional significance.