Therapeutic implications of the mGluR theory of fragile X mental retardation

作者：Mark F. Bear · 发表于：Genes Brain & Behavior · 年份：2005 · DOI：10.1111/j.1601-183x.2005.00135.x · 被引用次数：137 · 研究领域：Genetics and Neurodevelopmental Disorders、Neuroscience and Neuropharmacology Research、Pancreatic function and diabetes

Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.