Perfusion vector—a new method to quantify myocardial perfusion scintigraphy images: a simulation study with validation in patients

作者：David Minarik, Martin Senneby, Per Wollmer, Alva Mansten, Karl Sjöstrand, Lars Edenbrandt, Elin Trägårdh · 发表于：EJNMMI Research · 年份：2015 · DOI：10.1186/s13550-015-0121-3 · 被引用次数：3 · 研究领域：Cardiac Imaging and Diagnostics、Cardiovascular Function and Risk Factors、Cardiac Structural Anomalies and Repair

BACKGROUND: The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective quantitative method for further assisting the visual interpretation and to test the concept using simulated MPS images as well as patients. METHODS: The perfusion vector is based on calculating the difference between the anatomical centroid and the perfusion center of gravity of the left ventricle. Simulated MPS images were obtained using the SIMIND Monte Carlo program together with XCAT phantom. Four different-sized anterior and four lateral defects were simulated, and perfusion vector components x-, y-, and z-axes were calculated. For the patient study, 40 normal and 80 abnormal studies were included. Perfusion vectors were compared between normal and abnormal (apical, inferior, anterior, and lateral ischemia or infarction) studies and also correlated to the defect size. RESULTS: For simulated anterior defects, the stress perfusion vector component on the y-axis (anterior-inferior direction) increased in proportion to the defect size. For the simulated lateral defects, the stress perfusion vector component on the x-axis (septal-lateral direction) decreased in proportion to the defect size. When comparing normal and abnormal patients, there was a statistically significant difference for the stress perfusi...