mmr , a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors

作者：Edda De Rossi, Manuela Branzoni, Rita Cantoni, Anna Milano, Giovanna Riccardi, O. Ciferri · 发表于：Journal of Bacteriology · 年份：1998 · DOI：10.1128/jb.180.22.6068-6071.1998 · 被引用次数：108 · 研究领域：Tuberculosis Research and Epidemiology、Mycobacterium research and diagnosis、Pneumocystis jirovecii pneumonia detection and treatment

The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.