Children of the 90s: ethical guidance for a longitudinal study

作者：S E Mumford · 发表于：Archives of Disease in Childhood Fetal & Neonatal · 年份：1999 · DOI：10.1136/fn.81.2.f146 · 被引用次数：24 · 研究领域：Health, Environment, Cognitive Aging、Birth, Development, and Health、Epigenetics and DNA Methylation

Children of the Nineties (ALSPAC) is a major longitudinal study of pregnancy and childhood. From its beginnings in 1990, it has had its own multidisciplinary ethics and law committee, with several interesting features. The committee is specific to this study and has a broad remit which has allowed it to be involved in planning the study as a whole, approving individual projects, and responding to ethical issues as they arise. This article is the first of two covering the early work of the committee, the decision to establish a separate ethics committee and its initial role in formulating policies for ethical conduct in obtaining data from questionnaires, biological samples, and clinical and environmental tests. The intention is to offer readers the opportunity to consider theoretical questions of ethics in epidemiological research against the perspective of the real issues faced by one committee. By looking at the way in which this committee’s policies evolved, others may find useful strategies for dealing with similar dilemmas. Children of the Nineties or ALSPAC (the Avon Longitudinal Study of Pregnancy and Childhood) is a major epidemiological study of the 14 000 babies born in the Bristol area between April 1991 and December 1992.1 The study began in pregnancy and will follow the children up to age 7 and beyond; dozens of research groups have already made use of the ALSPAC data, investigating a variety of facets of child health and development. ALSPAC data come from sev...