Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs

作者：D S Rampton, Gordon E. Sladen · 发表于：Postgraduate Medical Journal · 年份：1981 · DOI：10.1136/pgmj.57.667.297 · 被引用次数：150 · 研究领域：Helicobacter pylori-related gastroenterology studies、Inflammatory mediators and NSAID effects、Inflammatory Bowel Disease

In four patients with inactive ulcerative proctocolitis, oral administration of non-steroidal anti-inflammatory drugs appeared to precipitate relapse. These observations suggest that inhibitors of prostaglandin synthesis should be used with care in patients with this disease, and are consistent with the hypothesis that prostaglandins may have a protective role in the lower as well as the upper gastrointestinal tract.