The molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research

作者：Michael M. Gottesman, Victor Ling · 发表于：FEBS Letters · 年份：2005 · DOI：10.1016/j.febslet.2005.12.060 · 被引用次数：555 · 研究领域：Drug Transport and Resistance Mechanisms、DNA and Nucleic Acid Chemistry、Trace Elements in Health

The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery.