Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*

作者：George A. Burghen, James R. Givens, Abbas E. Kitabchi · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：1980 · DOI：10.1210/jcem-50-1-113 · 被引用次数：920 · 研究领域：Ovarian function and disorders、Hormonal and reproductive studies、Growth Hormone and Insulin-like Growth Factors

We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obese women: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P less than 0.02 to P less than 0.001) in PCOD patients. A significant correlation among basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P less than 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.