A bisamide and four diketopiperazines from a marine-derived Streptomyces sp.

作者：Bin Li, Gang Chen, Jiao Bai, Yongkui Jing, Yue‐Hu Pei · 发表于：Journal of Asian Natural Products Research · 年份：2011 · DOI：10.1080/10286020.2011.617744 · 被引用次数：27 · 研究领域：Microbial Natural Products and Biosynthesis、Chemical Synthesis and Analysis、Synthesis and Biological Activity

A new bisamide N₁-acetyl-N₇-phenylacetyl cadaverine (1) and a series of diketopiperazines including a new diketopiperazine cyclo(2-hydroxy-Pro-R-Leu) (2), together with a new natural product cyclo(4-hydroxy-S-Pro-S-Trp) (3) and two known leucine-based diketopiperazines cyclo(4-hydroxy-R-Pro-S-Leu) (4) and cyclo (S-Pro-R-Leu) (5), were isolated from ethyl acetate extract of a fermentation broth of a marine-derived Streptomyces sp. Their structures were elucidated by the interpretation of spectroscopic analysis. The antitumor activities of compounds 1-3 against HL-60 cell lines were tested by MTT assay.