Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

作者：Joshua A. Jackman, Rathi Saravanan, Yibang Zhang, Seyed R. Tabaei, Nam‐Joon Cho · 发表于：Small · 年份：2015 · DOI：10.1002/smll.201403638 · 被引用次数：39 · 研究领域：Antimicrobial Peptides and Activities、Lipid Membrane Structure and Behavior、RNA Interference and Gene Delivery

The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.