Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005

作者：Sean F. Altekruse, Katherine A. McGlynn, Marsha E. Reichman · 发表于：Journal of Clinical Oncology · 年份：2009 · DOI：10.1200/jco.2008.20.7753 · 被引用次数：1699 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Multiple and Secondary Primary Cancers、Biological Research and Disease Studies

PURPOSE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Incidence rates are increasing in the United States. Monitoring incidence, survival, and mortality rates within at-risk populations can facilitate control efforts. METHODS: Age-adjusted incidence trends for HCC were examined in the Surveillance, Epidemiology, and End Results (SEER) registries from 1975 to 2005. Age-specific rates were examined for birth cohorts born between 1900 and 1959. Age-adjusted incidence and cause-specific survival rates from 1992 to 2005 were examined in the SEER 13 registries by race/ethnicity, stage, and treatment. United States liver cancer mortality rates were also examined. RESULTS: Age-adjusted HCC incidence rates tripled between 1975 and 2005. Incidence rates increased in each 10-year birth cohort from 1900 through the 1950s. Asians/Pacific Islanders had higher incidence and mortality rates than other racial/ethnic groups, but experienced a significant decrease in mortality rates over time. From 2000 to 2005, marked increases in incidence rates occurred among Hispanic, black, and white middle-aged men. Between 1992 and 2004, 2- to 4-year HCC survival rates doubled, as more patients were diagnosed with localized and regional HCC and prognosis improved, particularly for patients with reported treatment. Recent 1-year survival rates remained, however, less than 50%. CONCLUSION: HCC incidence and mortality rates continue to increase, particularly among...