Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction

作者：Theophilus Owan, David O. Hodge, Regina M. Herges, Steven J. Jacobsen, Veronique Lee Roger, Margaret M. Redfield · 发表于：New England Journal of Medicine · 年份：2006 · DOI：10.1056/nejmoa052256 · 被引用次数：4233 · 研究领域：Heart Failure Treatment and Management、Cardiovascular Function and Risk Factors、Cardiac pacing and defibrillation studies

BACKGROUND: The prevalence of heart failure with preserved ejection fraction may be changing as a result of changes in population demographics and in the prevalence and treatment of risk factors for heart failure. Changes in the prevalence of heart failure with preserved ejection fraction may contribute to changes in the natural history of heart failure. We performed a study to define secular trends in the prevalence of heart failure with preserved ejection fraction among patients at a single institution over a 15-year period. METHODS: We studied all consecutive patients hospitalized with decompensated heart failure at Mayo Clinic Hospitals in Olmsted County, Minnesota, from 1987 through 2001. We classified patients as having either preserved or reduced ejection fraction. The patients were also classified as community patients (Olmsted County residents) or referral patients. Secular trends in the type of heart failure, associated cardiovascular disease, and survival were defined. RESULTS: A total of 6076 patients with heart failure were discharged over the 15-year period; data on ejection fraction were available for 4596 of these patients (76 percent). Of these, 53 percent had a reduced ejection fraction and 47 percent had a preserved ejection fraction. The proportion of patients with the diagnosis of heart failure with preserved ejection fraction increased over time and was significantly higher among community patients than among referral patients (55 percent vs. 45 percent)...