An endothelial cell-derived growth factor.

作者：Corinne M. Gajdusek, Paul E. DiCorleto, Russell Ross, Stephen Mark Schwartz · 发表于：The Journal of Cell Biology · 年份：1980 · DOI：10.1083/jcb.85.2.467 · 被引用次数：317 · 研究领域：Cancer, Hypoxia, and Metabolism、Mesenchymal stem cell research、Ubiquitin and proteasome pathways

Cell-free plasma-derived serum (PDS) is deficient in the platelet-derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex.