Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii

作者：Inge Seim, Xiaodong Fang, Zhiqiang Xiong, Alexey V. Lobanov, Zhiyong Huang, Siming Ma, Yue Feng, Anton A. Turanov, Yabing Zhu, Tobias L. Lenz, Maxim V. Gerashchenko, Dingding Fan, Sun Hee Yim, Xiaoming Yao, Daniel M. Jordan, Yingqi Xiong, Yong Ma, Andrey N. Lyapunov, Guanxing Chen, О. И. Кулакова, Yudong Sun, Sang‐Goo Lee, Roderick T. Bronson, Alexey Moskalev, Shamil Sunyaev, Guojie Zhang, Anders Krogh, Jun Wang, Vadim N. Gladyshev · 发表于：Europe PMC (PubMed Central) · 年份：2013 · DOI：10.1038/ncomms3212 · 被引用次数：283 · 研究领域：Bat Biology and Ecology Studies、Physiological and biochemical adaptations、Environmental and Biological Research in Conflict Zones

Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.