Incidence of Late-Stage Age-Related Macular Degeneration in American Whites: Systematic Review and Meta-analysis

作者：Alicja Regina Rudnicka, Venediktos Kapetanakis, Zakariya A. Jarrar, Andrea K Wathern, Richard Wormald, ASTRID E. FLETCHER, Derek G. Cook, Christopher G. Owen · 发表于：American Journal of Ophthalmology · 年份：2015 · DOI：10.1016/j.ajo.2015.04.003 · 被引用次数：182 · 研究领域：Retinal Diseases and Treatments、Ophthalmology and Visual Impairment Studies、Retinal Imaging and Analysis

PURPOSE: To estimate incidence of age-related macular degeneration (AMD) by subtype in American whites aged ≥50 years. DESIGN: Systematic review and meta-analysis. SETTING: Prospective cohort studies of AMD incidence in populations of white European ancestry published in MEDLINE, EMBASE, and Web of Science. STUDY POPULATION: Fourteen publications in 10 populations that examined AMD incident cases were identified. OBSERVATION PROCEDURE: Data on age-sex-specific incidence of late AMD, geographic atrophy (GA) and neovascular AMD (NVAMD), year of recruitment, AMD grading method, and continent were extracted. MAIN OUTCOME MEASURE(S): Annual incidence of late AMD, GA, and NVAMD by age-sex in American whites aged ≥50 years from a Bayesian meta-analysis of incidence studies was compared with incidence extrapolated from published prevalence estimates. RESULTS: Incidence rates from the review agreed with those derived from prevalence, but the latter were based on more data, especially at older ages and by AMD subtypes. Annual incidence (estimated from prevalence) of late AMD in American whites was 3.5 per 1000 aged ≥50 years (95% credible interval 2.5, 4.7 per 1000), equivalent to 293 000 new cases in American whites per year (95% credible interval 207 000, 400 000). Incidence rates approximately quadrupled per decade in age. Annual incidence GA rates were 1.9 per 1000 aged ≥50 years, NVAMD rates were 1.8 per 1000. Late AMD incidence was 38% higher in women vs men (95% credible interva...