Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

作者：Yujin Zhu, Yanjun Zhang, Yi Liu, Hongwan Chu, Hong‐Quan Duan · 发表于：Molecules · 年份：2010 · DOI：10.3390/molecules15129174 · 被引用次数：36 · 研究领域：Natural product bioactivities and synthesis、Phytochemical compounds biological activities、Synthesis of Organic Compounds

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.