Region-Specific Fat Mass and Muscle Mass and Mortality in Community-Dwelling Older Men and Women

作者：Hanneke A. H. Wijnhoven, Marieke B. Snijder, Marian A.E. de van der Schueren, Dorly J. H. Deeg, Marjolein Visser · 发表于：Gerontology · 年份：2011 · DOI：10.1159/000324027 · 被引用次数：39 · 研究领域：Nutrition and Health in Aging、Body Composition Measurement Techniques、Frailty in Older Adults

BACKGROUND: Increased mortality risk at low body mass index values is well established for older persons. It is, however, unclear how the underlying body mass components (fat and muscle mass - FM and MM, respectively) are associated with mortality in old age. OBJECTIVE: This study aimed to examine the mortality risk of four body composition measures (appendicular skeletal MM, leg, arm and trunk FM) with 12-year mortality in community-dwelling older men and women. As a secondary objective, the influence of cancer, obstructive lung disease, smoking and previous weight loss on these associations was examined. METHODS: Data were used from the Longitudinal Aging Study Amsterdam, a random population-based cohort study (55-85 years) in the Netherlands. Body composition was determined in 1995-1996 by dual energy X-ray absorptiometry. The present study included 477 community-dwelling persons aged ≥65 years who were followed until 2007 for their vital status. RESULTS: Twelve-year mortality rates were 133/242 (55%) in men and 92/235 (39%) in women. Since most associations were U- or J-shaped, only observations below the sample mean were included to calculate hazard ratios (HRs) per one SD lower value. Adjusted for height, age and each other, lower appendicular skeletal MM [HR 1.59 (95% CI: 1.04-2.42)] and lower leg FM [1.68 (1.04-2.72)] in men and lower trunk FM [1.61 (1.02-2.53)] in women were associated with an increased mortality risk. Associations attenuated and became statistically...