Role of CCAA Nucleotide Repeats in Regulation of Hemoglobin and Hemoglobin-Haptoglobin Binding Protein Genes of Haemophilus influenzae

作者：Zhen Ren, Hongfan Jin, Paul W. Whitby, Daniel J. Morton, Terrence L. Stull · 发表于：Journal of Bacteriology · 年份：1999 · DOI：10.1128/jb.181.18.5865-5870.1999 · 被引用次数：56 · 研究领域：RNA and protein synthesis mechanisms、Bacterial Genetics and Biotechnology、Hemoglobin structure and function

Haemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as heme sources. The H. influenzae hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZ translational gene fusion, we demonstrate phase-variable expression of lacZ associated with alteration in the length of the CCAA repeat region.