Oligo- and poly-nucleotides: 50 years of chemical synthesis

作者：Colin B. Reese · 发表于：Organic & Biomolecular Chemistry · 年份：2005 · DOI：10.1039/b510458k · 被引用次数：190 · 研究领域：DNA and Nucleic Acid Chemistry、Advanced biosensing and bioanalysis techniques、Chemical Synthesis and Analysis

It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3'-->5'-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.