Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

作者：I. Stuart Wood, Paul Trayhurn · 发表于：British Journal Of Nutrition · 年份：2003 · DOI：10.1079/bjn2002763 · 被引用次数：890 · 研究领域：Metabolism, Diabetes, and Cancer、Pancreatic function and diabetes、Diabetes Treatment and Management

The number of known glucose transporters has expanded considerably over the past 2 years. At least three, and up to six, Na+-dependent glucose transporters (SGLT1-SGLT6; gene name SLC5A) have been identified. Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1-GLUT12 and HMIT; gene name SLC2A) are now recognised. These various transporters exhibit different substrate specificities, kinetic properties and tissue expression profiles. The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable complexity.