THE EFFECT OF ACETYLSALICYLIC ACID ON PLATELET FUNCTION

作者：Geoffrey M. Evans, Marian A. Packham, Edward E. Nishizawa, James F. Mustard, Edmund A. Murphy · 发表于：The Journal of Experimental Medicine · 年份：1968 · DOI：10.1084/jem.128.5.877 · 被引用次数：283 · 研究领域：Complement system in diseases、Platelet Disorders and Treatments、Mechanical Circulatory Support Devices

Acetylsalicylic acid (ASA, aspirin) and sodium salicylate inhibit platelet aggregation induced by collagen, antigen-antibody complexes, gamma globulin-coated particles or thrombin. These compounds suppress the release of platelet constituents, such as adenosine diphosphate (ADP) and serotonin, induced by such stimuli. Since ASA and sodium salicylate do not inhibit ADP-induced platelet aggregation, it appears that their effect on the action of the other stimuli is due to a decrease in the amount of ADP released. The administration of ASA to rabbits (in doses which inhibited collagen-induced platelet aggregation) impaired hemostasis, prolonged platelet survival, and diminished the amount of deposit formed in an extracorporeal shunt.