Clinical Importance and Epidemiology of Quinolone Resistance

作者：Eu Suk Kim, David C. Hooper · 发表于：Infection and Chemotherapy · 年份：2014 · DOI：10.3947/ic.2014.46.4.226 · 被引用次数：101 · 研究领域：Antibiotics Pharmacokinetics and Efficacy、Pneumonia and Respiratory Infections、Bacterial Identification and Susceptibility Testing

The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has emerged and increased globally. This resistance limits the usefulness of quinolones in clinical practice. The review summarizes mechanisms of quinolone resistance and its epidemiology and implications in the most common clinical settings, urinary tract infections, respiratory tract infections, intraabdominal infections, skin and skin structure infections, and sexually transmitted diseases.