Generating samples under a Wright–Fisher neutral model of genetic variation

作者：Richard R. Hudson · 发表于：Bioinformatics · 年份：2002 · DOI：10.1093/bioinformatics/18.2.337 · 被引用次数：2590 · 研究领域：Scientific Research and Discoveries、Gaussian Processes and Bayesian Inference、Soil Geostatistics and Mapping

Abstract Summary: A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright–Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric migration among subpopulations, and a variety of demographic histories. The samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models. Availability: The source code for the program (in the language C) is available at http://home.uchicago.edu/~rhudson1/source/mksamples.html. Contact: rr-hudson@uchicago.edu