C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.

作者：Seijiro Okusawa, Kim B. Yancey, Jos WM van der Meer, Stefan Endres, Gerhard Lonnemann, K. Hefter, Magdalena Frank, John Frederick Burke, Charles Anthony Dinarello, Jeffrey A. Gelfand · 发表于：The Journal of Experimental Medicine · 年份：1988 · DOI：10.1084/jem.168.1.443 · 被引用次数：212 · 研究领域：Immune Response and Inflammation、Hematological disorders and diagnostics、Erythrocyte Function and Pathophysiology

We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-alpha, IL-1 beta, and IL-1 alpha, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-alpha and IL-1 beta secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1 alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.